Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2007, Cilt 5, Sayı 2, Sayfa(lar) 063-067
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Relationship Between C-Reactive Protein, Glucose and Age
Rabia Nur Kocabaş1, A. Erkin Bozdemir2, Güneş Başol2, Burcu Barutçuoğlu2, Zuhal Parıldar2, Ceyda Kabaroğlu2, Oya Bayındır2
1Ege Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, İzmir
2Ege Üniversitesi Tıp Fakültesi, Klinik Biyokimya Bilim Dalı, İzmir
Keywords: Age, cardiovascular disease risk, CRP, glucose, inflammation

Objective: Cardiovascular diseases (CVD) are the leading causes of death worldwide. After understanding the importance of inflammation in the pathogenesis, CRP usage has been increased for the determination of cardiovascular risk. As an inflammation marker, the relationship between CRP levels and CVD risk and age has already been shown. In this study our purpose is to investigate the relationships between CRP, glucose and age.

Materials and Methods: CRP, glucose levels an d ages were analysed retrospectively in subjects admitted to the laboratory in 2005. Correlations were examined between CRP, glucose levels and ages.

Results: CRP, glucose levels and ages of 1071 females, 1179 males, overall 2250 cases were 0.483±0.021 mg/dL (mean±SEM), 106.8±0.7 mg/dL and 52.73±0.31 respectively. Weak positive correlations were found between CRP and glucose; and glucose and age in whole group (r= 0.128, p=0.000 and r= 0.155, p=0.000, respectively). Cases were divided into two groups, according to their cardiovascular disease risk cut-off value (Group A: CRP<0.300 mg/dL, Group B: CRP≥0.300 mg/dL). Glucose levels and ages were found to be significantly higher in group B (p=0.000 ve p=0.000, respectively). In group B, significant positive correlation was determined between CRP and glucose levels (r=0.090, p=0.006). In group A, significant positive correlations were determined between CRP and glucose, CRP and age; and glucose and age (r= 0.093, p=0.001 and r= 0.159, p=0.000 and r= 0.246, p=0.000, respectively).

Conclusion: In this retrospective study significant positive correlations were found between CRP, glucose and age in Group A; and between CRP and glucose in Group B. These findings support that ageing may be a minimal inflammatory process.


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