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2005, Cilt 3, Sayı 1, Sayfa(lar) 023-026
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Protein C and Free Protein S Levels in Type 2 Diabetic Patients
Nazan Tunçbilek1, AsumanOrçun1, Nuray Kolcu1, Mehmet Sargın2, İnci Küçükercan1, Gülcan Baloğlu1
1Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi Biyokimya Bölümü, İstanbul
2Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi Endokrinoloji/Diyabet Bölümü, İstanbul
Keywords: Diabetes mellitus, Protein C, Protein S, thrombosis

Objective: A natural anticoagulant Protein C and its cofactor free Protein S, play an important role in the development of thrombosis in diabetics. In this study, we compared Protein C and Protein S concentrations in type 2 diabetic patients and healthy controls and observed their changes between well and poor controlled diabetics.

Method: 30 diabetic patients (age mean 58.66±7.42 years) consisted of 18 women and 12 men and 20 healthy controls (age mean 55.05±5.28 years) consisted of 13 women and 7 men. Patient group was subdivided according to their HbA1c levels as well controlled (HbA1c²%8.0), (n=29) and poor controlled (HbA1c>8.0%), (n=11) diabetics. Protein C and free Protein S, glucose, microalbumin/creatinine and HbA1c concentrations of all individuals were determined. Percent activities of Protein C and free Protein S were determined by use of IL-test commercial kits on ACL Futura analyser (Instrumantation Lab, Milena, Italy). Non-parametric Mann-Whitney U and Spearman correlation tests were used in statistical calculations.

Results: Patient and control groups' Protein C activities were found 94.54%±16.4 and 119.23%±14.31 (p<0.0001), and free Protein S activities as 91.82%±13.72 and 101.26%±12.82 (p=0.028), respectively. Glucose, microalbumin/creatinine, HbA1c concentrations of 2 groups differed significantly from each other (p's<0.0001). In patient group, Protein C activities were inversely and weakly correlated with fasting plasma glucose (r=-0.208) and HbA1c (r=0.246), (p's<0.01) concentrations. Well controlled diabetic group's Protein C activities were (mean±SD) 109.35%±17.62, free Protein S activities were 96.60%±14.39; poor controlled diabetics' Protein C activities were 87.76%±17.04 and free Protein S activities were 91.98%±11.84. Protein C activities significantly differed between 2 groups (p=0.0019), free Protein S activities didnot show a significant difference (p=0.29).

Conclusion: In this study we found serum Protein C and free Protein S activities were significantly lower in type 2 diabetics than in healthy controls and concluded that they may be efficient in the pathogenesis of diabetes mellitus.


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