2018, Cilt 16, Sayı 2, Sayfa(lar) 109-116 |
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Determination of age-dependent reference ranges for PT and Aptt |
Şerif Ercan1, Salih Karaca2, Mahmut Çakır3 |
1Lüleburgaz Devlet Hastanesi, Tıbbi Biyokimya , Kırklareli, Türkiye 2Lüleburgaz Devlet Hastanesi, Çocuk Cerrahisi Kliniği, Kırklareli, Türkiye 3Lüleburgaz Devlet Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Kırklareli, Türkiye |
Keywords: Blood coagulation tests, partial thromboplastin time, pediatrics, prothrombin time, reference values |
Purpose: The maturation of hemostatic system continues from fetal life to adult. Determination of agedependent
reference ranges for coagulation is therefore very important to evaluate correctly the
hemostasis. The study aimed to establish age-dependent reference range for prothrombin time (PT)
and activated partial thromboplastin time (aPTT) as well compare pediatric and adult reference ranges.
Materials and Methods: Pediatric and adult patients who were requested PT and aPTT tests for the
preoperative evaluation before minor elective surgery were enrolled in the study. Patients were
separated into four groups (Group 1: 1-5 years old; Group 2: 6-10 years old; Group 3: 11-16 years old
and Group 4: ≥18 years old). PT and aPTT were measured on SF8100 (Beijing Succeeder, China)
coagulation analyzer by mechanic coagulometric method. Reagents were same brand with the
coagulation analyzer. Reference ranges were determined by the non-parametric method or Robust
method according to the sample size of groups. The z test was used to compare pediatric and adult
reference ranges.
Results: 473 pediatric [Group 1 (n=120), Group 2 (n=324) and Group 3 (n=29)] and 143 adult
patients were included into the study. The reference ranges for PT determined in pediatric groups were
found to be similar to those of adult (calculated z value < critical z value). aPTT reference ranges were
significantly higher in pediatric groups than that of adult group (calculated z value > critical z value).
Conclusion: aPTT reference range determined in pediatric population was longer time than that of
adult population. Therefore, to prevent falsely abnormal classifications, the age-specific reference
ranges should be used during evaluating aPTT results in the pediatric population.
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