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2013, Cilt 11, Sayı 2, Sayfa(lar) 051-057
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Evaluating Pregnancy-Associated Plasma Protein A (PAPP-A) and Insulin-like growth factor I (IGF-I) Levels in Patients with Acute Coronary Syndrome
Şahika Özen Eren1, Bünyamin Kaptanoğlu2, Hülya Aybek2, Mahmut Şenyurt3, Mert Özen4
1Servergazi Devlet Hastanesi, Tıbbi Biyokimya, Denizli
2Pamukkale Üniversitesi Tıp Fakültesi Tıbbi Biyokimya Anabilim Dalı, Denizli
3Erzurum Bölge Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, Erzurum
4Denizli Devlet Hastanesi, Acil Tıp, Denizli
Keywords: Acute coronary syndrome; PAPP-A; IGF-I

Objective: In this study, we aimed to investigate the importance of serum pregnancy associated plasma protein A (PAPP-A) levels as an early marker before an acute myocardial infarction due to a high risk atherosclerotic plaque rupture and the relationship between PAPP-A and insulin like growth factor I (IGF-I).

Materials and Methods: Serum PAPP-A and IGF-I levels were determined in 41 patients diagnosed as ACS and 39 healthy individuals.

Results: P APP-A levels in the patient group was significiantly higher than the control group (p=0.0001). On the other hand, no significiant difference was found between the groups regarding IGF-I levels (p=0.882). A positive, weak, statistically non-significiant corelation was found between PAPP-A and IGF-I levels (r=0.018, p=0.875). A receiver-operating curve (ROC) was plotted to determine the effectiveness of PAPP-A levels in differentiating the patients with acute coronary syndrome from the healthy individuals. The area under the curve was calculated as 0.858 (p=0.0001). Choosing 1.945 mIU/L as the cut-off point, a sensitivity of 85.4% and a spesificity of 82.1% were revealed.

Conclusion: Although our results support that PAPP-A might be a useful marker for the diagnosis of acute coronary syndrome, prospective studies conducted in larger patient groups are required to explain the role of IGF-I and its relation with PAPP-A in acute coronary syndrome.

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