2020, Cilt 18, Sayı 3, Sayfa(lar) 121-128 |
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A Prospective Evaluation of Vascular Calcification Markers in Renal Transplantation |
Bilge Karatoy Erdem1, Vural Taner Yılmaz2, Gültekin Süleymanlar2, Ayhan Dinckan3, Halide Akbas1 |
1Akdeniz Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Antalya, Türkiye 2Akdeniz Üniversitesi Tıp Fakültesi, Nefroloji Bilim Dalı, Antalya, Türkiye 3Akdeniz Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Antalya, Türkiye |
Keywords: renal transplant, vascular calcification, biomarkers, Fetuin A, PPi |
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Aim: The evaluation of biomarkers linked with inhibition and activation of vascular calcification in pre
and post renal transplant period in renal transplant recipients was aimed in this research.
Patients and Methods: 35 recipients who had undergone living-donor kidney transplantation were
included. Plasma 1,25-dihydroxyvitamin D3, serum 25-hydroxyvitamin D3, calcium, phosphorus,
inorganic pyrophosphate (PPi), osteoprotegerin (OPG), alpha-2 heremans-schmid glycoprotein (Fetuin-
A), alkaline phosphatase (ALP), bone morphogenic protein-2 (BMP-2), creatinine, parathyroid hormone
(PTH) levels were analyzed immediately before and 6 months after transplantation. Statistical analysis
was done using SPSS version 20.0.
Results: This research reported that vitamin D deficiency continues independently of renal function in
renal transplant recipients. Despite the low levels of vitamin D, its active form was increased with the
improvement of renal function. It also observed that PPi and Fetuin-A levels increase, OPG and ALP
levels decrease with the improvement of graft function.
Conclusion: Serum biomarkers could serve as important indicators of vascular calcification in renal
transplant recipients. The increase in serum levels of OPG and ALP, which are thought to play a role as
activators in the calcification process in patients with Chronic Kidney Disease may be beneficial in early
detection of calcification. Further larger studies are required to evaluate time-dependent changes after
renal transplantation. |
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Abstract
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