Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2007, Cilt 5, Sayı 3, Sayfa(lar) 117-125
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Hepcidin, A New Regulator of Iron Homeostasis
Güneş Başol, Burcu Barutçuoğlu, A. Erkin Bozdemir
Ege Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Klinik Biyokimya Bilim Dalı, İzmir
Keywords: Hepcidin, iron homeostasis, anemia of inflammation, hemochromatosis

Hepcidin, a recently discovered peptide hormone, is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages and iron mobilization from hepatic stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin. Hepcidin synthesis is increased by iron loading and decreased by anemia and hypoxia. Additionally, hepcidin synthesis is greatly induced during inflammation, trapping iron in macrophages, decreasing plasma iron concentrations and causing anemia of inflammation. Recent studies indicate that hepcidin deficiency underlies most known forms of hereditary hemochromatosis. The discovery of hepcidin and its role in iron metabolism could lead to new therapies for anemia of inflammation and hemochromatosis.

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