| 2003, Cilt 1, Sayı 2, Sayfa(lar) 055-060 |
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LBP, TNF- α and CRP Levels in a Caecal Ligation and E. Coli Model of Sepsis in Rats |
Baysal Karaca1, Nuriye Uzuncan1, Osman Evliyaoğlu1, Ayşe Arısoy2, Ayten Coşkuner3, Onur Özgenç3 |
1SSK İzmir Eğitim Hastanesi Biyokimya Kliniği, İzmir
2Celal Bayar Ünv. Tıp Fakültesi Enfeksiyon Hastalıkları Kliniği, İzmir
3SSK İzmir Eğitim Hastanesi Enfeksiyon Hastalıkları Kliniği, İzmir |
Keywords: Caecal Ligation, LBP, TNF, IL-6, CRP |
Sepsis is defined as systhemic response against infections and frequently caused by gram negative bacteria. It is proposed that the blood levels of acute phase reactants such as Lipopolisaccharide Binding Protein (LBP), C-reactive protein (CRP), mediators of septic cells such as Tumor Necrosis Factor (TNF) and cytokine IL-6 increases in case of an endotoxin.
In order to evaluate the cellular response and the difference between case and control groups, we determined the serum levels of LBP, TNF, IL-6 and CRP levels in 21 rats which were undergone caecal ligation puncture procedure and intraperitoneal E.Coli injection to evolve sepsis. There was not a statistically significant difference between control group. Group I whose hemoculture result was normal flora and group II whose hemoculture result was E. Coli positive (p>0.05).
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