2003, Cilt 1, Sayı 1, Sayfa(lar) 041-046 |
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Glutathione Related Enzymes in Renovascular Hypertension Effect of Endovascular Treatment |
Zuhal Parıldar1, Mustafa Parıldar2, Ceyda Kabaroğlu1, Nevbahar Turgan1, Işıl Mutaf1, Ahmet Memiş2, Dilek Erdener1 |
1Ege Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Klinik Biyokimya Bilim Dalı, İzmir 2 Ege Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, İzmir |
Keywords: Renovascular hypertension, oxidative stress, erythrocyte glutathione related enzymes, endovascular therapy |
Purpose: Activation of the renin-angiotensin system leads to an increase in oxidative stress. We investigated erythrocyte antioxidant enzymes, glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities and as an index for oxidative stress plasma malondialdehyde levels and the effect of endovascular treatment on these parameters in renovascular hypertensive patients.
Methods: In 28 patients with unilateral renal artery stenosis, plasma malondialdehyde; erythrocyte glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities were investigated at entry and after 24 hours of endovascular treatment and compared with controls.
Results: Malondialdehyde concentrations were higher in patients than controls and decreased 24 hours after the intervention. Erythrocyte glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities were significantly higher in patients than controls. However, their activities did not differ after the intervention. After the treatment blood pressures decreased.
Conclusion: Oxidative stress and glutathione related enzyme activities are increased in renovascular hypertension. The increase in the enzyme activities could be attributed to a defence mechanism against oxidative stress. Endovascular treatment decrease the oxidative stress without affecting the glutathione peroxidase, glutathione reductase and glutathione-S-transferase enzyme activities.
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