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2006, Cilt 4, Sayı 2, Sayfa(lar) 059-063
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Association Between High Sensitive C-reactive Protein (hsCRP) and Total Cholesterol, LDL-Cholesterol, HDL-Cholesterol and Triglyceride Levels
Can Duman1, Emin Alioğlu2
1Kocaeli Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Kocaeli
2Central Hospital Kardiyoloji Kliniği, İzmir
Keywords: hsCRP, total cholesterol, Triglyceride, HDL cholesterol, LDL cholesterol, atherosclerosis

Objective: It is well known that chronic inflammation is an important factor of the process which leads to atherosclerosis. While leading to atherosclerosis inflammation can cause acute phase response as well. CRP, serologic indicator of inflamation, synthesized in liver, is significant for prognosis. hsCRP is newly assumed to be more powerful than LDL cholesterol in determining the cardiovascular event as a prognostic factor. In studies investigating the association between cardiovascular risk factors, different correlations are to be seen between hsCRP levels, and serum triglyceride, total, LDL ve HDL-cholesterol. We aimed to evaluate this association between hsCRP levels, and serum triglyceride, total, LDL ve HDL-cholesterol.

Material and Method: In this study, the association between serum hsCRP levels and serum triglyceride, total, LDL ve HDL-cholesterol levels of 273 healthy people with no cardiovascular pathology, diabetes and hypertension, admitted to the center laboratory of Kocaeli University between 29th September 2003 and 13th July 2004, was investigated.

Results: There was significant but very low level correlation between total cholesterol and hsCRP found in this study (r=-0.15, p=0.01). The correlation between HDL cholesterol and hsCRP was negative and low level and statistically significant (r=-0.22, p=0.001). There was no significant correlation between hsCRP and LDL cholesterol or triglyceride levels.

Conclusion: The negative correlation we found in our study between hsCRP and HDL cholesterol levels are compatible with literature. Most probably because of insufficient numbers of cases the correlation found in this study between total cholesterol and hsCRP is not consistent with literature. It seems that LDL cholesterol and triglycerid levels are independent from hsCRP levels.


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