Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2003, Cilt 1, Sayı 1, Sayfa(lar) 027-032
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The Association of Preeclampsia with Angiotensin-Converting Enzyme I/D Gene Polymorphism and Hyperhomocysteinemia
Elif İşbilen1, Yeşim Ünlüçerçi1, Figen Gürdöl1, Hülya Yılmaz2, Turgay İsbir2, Yavuz Ceylan3, Recep Has4
1İ.Ü. İstanbul Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul
2İ.Ü. Deneysel Tıp Araştırma Merkezi, Moleküler Tıp Anabilim Dalı, İstanbul
3SSK Bakırköy Hastanesi, Kadın Doğum ve Hastalıkları Kliniği, İstanbul
4İ.Ü. İstanbul Tıp Fakültesi, Kadın Doğum ve Hastalıkları Anabilim Dalı, İstanbul
Keywords: Preeclampsia, ACE gene, polymorphism, hyperhomocysteinemia

Hyperhomocysteinemia and increased ACE activity due to the deletion polymorphism of the ACE gene are two common features in a wide variety of pathological conditions that exhibit endothelial disturbances. In this study, we examined both the I/D genotype distribution and the activity of ACE in preeclamptic pregnants, and we evaluated the plasma homocysteine level whether it has any relation with the above-mentioned parameters. 95 preeclamptic, and 50 normotensive pregnant patients in their third trimester consisted the study groups. 39 healthy individuals with no history of pregnancy complications were included in the study as normotensive controls. ACE I/D gene polymorphism was studied in all subjects, and the prevalence of deletion polymorphism was found significant in the preeclamptics (p=0.0457; Odds Ratio 1.535; 95% CI=1.007-2.338). ACE activity in the sera of preeclamptics was found increased with regard to both normotensive controls and healthy pregnants (p<0.05). The influence of the allelic distribution on the enzyme activity was detected significantly in the preeclamptics bearing II genotype, whose exhibited lower activity than the patients with the other genotypes (p<0.02) in spite of the presence of hypertension. Plasma homocysteine concentrations were also elevated in preeclamptics (p<0.001), but this was not correlated with the ACE activity.

Our data indicate that ACE gene deletion allele, which causes high enzyme activity in circulation, may be associated with the occurrence of preeclampsia during pregnancy.


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