Purpose: We aimed to investigate pentraxin 3 and placental protein 13 levels related to the pathogenesis of the disease, as well as albumin, lactate dehydrogenase, uric acid and platelet count values, which are frequently requested laboratory tests, in second and third trimester pregnant women diagnosed with pre-eclampsia and to compare these results with healthy control group pregnant women.

Material and Methods: A total of 80 pregnant women aged between 20-40 years and 24-40 weeks of gestation (40 preeclampsia and 40 control) were included in the study. 32nd gestational week was taken as the limit and preeclampsia and control groups were divided into two subgroups. Albumin, lactate dehydrogenase and uric acid levels were analysed in blood samples by spectrophotometric method and the results were recorded. Pentraxin 3 and placental protein 13 levels were analysed by sandwich enzyme-linked immunosorbent assay. Complete blood count results were obtained from the hospital laboratory data system and platelet count values were recorded. In the statistical analyses of the study, mean±standard deviation values were used for data fitting the normal distribution, median, IQR (interquartile range) (25 p-75 p) and min.-max values were used for data not fitting the normal distribution.

Results: Placental protein 13 (PP-13), platelet count and albumin levels were significantly lower and lactate dehydrogenase and uric acid levels were significantly higher in the preeclampsia group compared to healthy controls (p<0.05). In addition, lactate dehydrogenase levels were significantly and negatively correlated with platelet count and albumin levels in preeclamptic pregnant women (p<0.05).

Conclusion: The fact that placental protein 13, platelet count and albumin values are lower and lactat dehydrogenase and uric acid values are higher in patients with pre-eclampsia may guide the use of laboratory tests when evaluating pre-eclamptic pregnant women.