EISSN: 2980-0749
  Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik İlkeler | İletişim  
2022, Cilt 20, Sayı 3, Sayfa(lar) 124-131
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
The Effect of Exercise Training on Circulating microRNAs Related to Lipid Metabolism
Kübra Kaya1, Fatma Humeyra Yerlikaya1, Galip Bilen2, Duygu Eryavuz Onmaz1
1Selçuk Üniversitesi, Tıp Fakültesi Biyokimya Anabilim Dalı, Konya, Türkiye
2Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Spor Hekimliği Anabilim Dalı, Konya, Türkiye
Keywords: Exercise, microRNA, lipid metabolism, cholesterol

Background: A sedentary lifestyle is associated with cardiometabolic risk factors and obesity. This study aims to investigate the effects of regular exercise training, acute exercise, and a sedentary lifestyle on levels of miRNA-33, miRNA-335, miRNA-370, miRNA-758, which play a regulatory role in lipid metabolism and contribute to the elucidation of the molecular mechanisms involved in the exercise.

Methods: The study included 30 elite taekwondo female athletes and 30 sedentary women who didn’t exercise regularly. Plasma miRNA-33, miRNA-335, miRNA-370, miRNA-758 levels were evaluated by using real-time quantitative PCR (RT-PCR) analysis. The levels of selected biochemical parameters were measured by a colorimetric method with an automated Architect C 8000 System (Abbott Laboratories, Abbott Park, IL, USA).

Results: Plasma miRNA-33 levels were found to be significantly higher in the pre-exercise [5.96 (1.48- 23.92), p<0.001] and post-exercise groups [6.82 (0.72-96.34), p<0.001] compared to the sedentary group [2.67 (0.12-8.88)]. miRNA-758 levels were lower in the post-exercise [0.0016 (0.0010-0.02)] group compared to the pre-exercise [0.0099 (0.0009-0.04), p<0.001] and sedentary groups [0.0123 (0.0011-0.04), p<0.001]. miRNA-370 levels were lower in the pre-exercise [3.11 (0.70-17.15)] group compared to the post-exercise [7.41 (2.81-56.89), p<0.001] and sedentary [8.17 (0.32-26.35), p<0.001] groups. There was no statistically significant difference between miRNA-335 levels (p>0.05).

Conclusions: Our findings suggest that regular exercise has a significant impact on lipid metabolism at the molecular level and miRNA-33, miRNA-370 and miRNA-758 play a key role in regulating the metabolic response to exercise.

[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik İlkeler | İletişim