2022, Cilt 20, Sayı 2, Sayfa(lar) 091-096 |
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Diurnal Rhythm and Postprandial Change in Thyroid Function Tests |
Alperen Halil İhtiyar1, Fatma Demet Arslan2, Mehmet Hicri Köseoğlu3 |
1Samsun Bafra Devlet Hastanesi, Tıbbi Biyokimya, Samsun, Türkiye 2Bakırçay Üniversitesi, Tıbbi Biyokimya, İzmir, Türkiye 3Tınaztepe Üniversitesi, Tıbbi Biyokimya, İzmir, Türkiye |
Keywords: Diurnal rhythm, TSH, thyroid hormones |
Objective: Thyroid function tests (TFT) are one of the most frequently requested biochemical
parameters by clinicians and can be requested at any time of the day. For this reason, we evaluated the
effects of diurnal variation and fasting-satiety status on TFT in order to make an accurate and reliable
decision in the diagnosis and follow-up of patients.
Material and Methods: Blood samples were taken from 16 healthy adult volunteers (11 males, 5
females) at 09.00, 10.00, 11.00, 12.00, 15.00, 18.00 and 24.00 hours. The samples taken at 09.00
were accepted as basal. Thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free
thyroxine (fT4) levels at other hours were compared with basal levels statistically and clinically.
Results: There was no clinically significant difference in fT4 concentrations during the day. TSH had a
variation up to (-27.37%)-(48.95%) within the day. The variations in fT3 (-5.59%) only at 15.00 and
18.00 were found clinically significant.
Conclusion: When evaluating TSH and fT3 test results, it was thought that diurnal variation should be
taken into account, and if not, blood sampling should be done at the same time in the morning.
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