2004, Cilt 2, Sayı 3, Sayfa(lar) 127-136 |
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Experimental Models of Diabetes Mellitus |
Seda V. İrer, Gülinnaz Alper |
Ege Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, İzmir |
Keywords: Experimental diabetes, Diabetes Mellitus, animal, rat |
In research studies performed to enlighten the diagnosis and pathogenesis of various diseases and to investigate possible treatment strategies, experimental animal models provide many advantages to the investigators. Diabetes Mellitus is a chronic metabolic disease which lasts for whole life, requiring continuous follow-up and therapy. With its acute and chronic complications, it decreases patient's lifespan and quality, causes a high morbidity and mortality rate and is a huge economic burden. Therefore clarifying its pathogenesis has a great value. In this review, experimental models and their application procedures used in research studies examining pathogenesis of diabetes and its therapoetic approaches are discussed.
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