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2021, Cilt 19, Sayı 3, Sayfa(lar) 212-218
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Effect of Smoking on First Trimester Screening Tests
Leyla Demir1, Serap Çuhadar2, Tuğba Öncel2, Saliha Aksun1, Figen Narin1
1İzmir Katip Çelebi Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir, Türkiye
2İzmir Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İzmir, Türkiye
Keywords: Prenatal screening, smoking, PAPP-A, free ß-HCG

Objective: First trimester screening tests are widely used for the diagnosis of chomosomal anomalies. In our study, we investigated the effect of maternal smoking on first trimester screening tests in pregnant women who applied to our laboratory.

Material and Methods: First trimester prenatal test results of a total of 900 pregnant women, 700 smokers and 200 non-smokers, were retrospectively collected. Maternal serum PAPP-A, free ß-HCG, fetal CRL and NT values of all pregnant women were compared statistically.

Results: When the first trimester screening test parameters of the smoker and non-smoker groups were compared, only a significant difference was found in the PAPP-A value (p = 0.023). Age (p = 0.088), PAPP-A MoM (p = 0.981), free ß-HCG (p = 0.668), free ß-HCG MoM (p = 0.782), NT MoM (p = 0.398) and CRL (p = 0.260) values did not differ significantly between the two groups.

Conclusion: Smoking in pregnant women decreases maternal serum PAPP-A level, one of the first trimester screening test parameters. Low serum PAPP-A level has been associated with chromosomal anomalies and other pregnancy complications such as preterm birth, pregnancy loss and low birth weight. As a conclusion, it may be beneficial to follow the pregnant women with low serum PAPP-A levels clinically more closely.


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