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2004, Cilt 2, Sayı 2, Sayfa(lar) 077-082
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The Comparison of Different Automation Systems with Reference Method for Erytrocyte Sedimentation Rate Measurement
Nalan Akalın, Serap Arıkan, Nagihan Türkeli, Turan Serter
Başkent Üniversitesi Alanya Araştırma ve Uygulama Merkezi Biyokimya Laboratuvarı, Ankara
Keywords: Westergren Method, Erythrocyte Sedimentation Rate (ESR), International Council for Standardization in Haematology (ICSH)

Purpose: In recent decades, several new techniques for measuring erytrocyte sedimentation rate have been developed in clinical laboratories. The aim of this study to compare three different automated sedimentation analyzers (Micro TEST-1, Sedisystem, Sed Rate Screener) with the manual Westergren reference method.

Materials and Methods: Patient blood samples were collected in K3EDTA vacutainers and in sodium citrate Vacu-Tec tubes and assayed within 4 hours of veinpuncture in three different sedimentation analyzer and manual Westergren method (n=40, 2-120 mm/h).

Results: The assays results of the automated sedimentation analyzers were statistically different from the manual Westergren method except Sedisystem (Sedisystem p=0.558, Micro TEST-1 p=0.034, Sed Rate Screener p=0.00 0). There were significantly high correlations between the results of sedimentation analyzers and the manuel Westergren method (Micro TEST-1 r= 0.712, Sedisystem r= 0.913, Sed Rate Screener r= 0.934, p values=0.000). The regression statistics obtained from the method comparison study were: Micro TEST-1; y = 0.80x + 0.56, Sedisystem; y = 1.10 x - 1.35, and Sed Rate Screener; y = 0.77x - 0.17.

Conclusion: The new fully automated systems for ESR measurement are safe, precise, accurate, and easy to use in clinical laboratories


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