2019, Cilt 17, Sayı 1, Sayfa(lar) 048-055 |
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New Parameters of Coronary Artery Diseases: Oxidative Stress Markers |
Uğur Erçin1, Ayşe Bilgihan2, Aycan Fahri Erkan3, Hayati Yücel4 |
1Halk Sağlığı Laboratuvarı, Tıbbi Biyokimya Laboratuvarı, Balıkesir, Türkiye 2Ufuk Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye 3Ufuk Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye 4Dr. Münif İslamoğlu Devlet Hastanesi, Acil Tıp, Kastamonu, Türkiye |
Keywords: Coronary artery disease; Oxidative stress; MDA(Malondialdehyde); AOPP(Advanced Oxidation Product of Proteins) |
Aim: The aim was to determine if the malondialdehyde (MDA) and advanced oxidation products of
protein (AOPPs) levels, which are oxidative stress parameters, can be used to determine the degree of
coronary artery disease.
Materials and Methods: The patients undergoing coronary angiography with the suspicion of coronary
artery disease were divided into three groups based on the severity of disease by a stenosis scoring,
Gensini scoring system. The patients with a Gensini score between 0 and 4 were assigned as Group I
(control group). Those with a Gensini score between 5-35 were assigned as Group II and those having
Gensini score >35 were as Group III. Plasma MDA levels were measured using a modification of the
chromatographic degradation of MDA hydrazone by high performance liquid chromotagraphy, whereas
plasma AOPP levels were measured spectrophotometrically.
Results: In the present study, a statistically significant difference was found between Group I and Group
III in terms of plasma MDA levels, which is an indicator of stress (p=0.048). There were statistically
significant differences between Group I and Group III and between Group II and Group III in terms of
plasma AOPP levels (p=0.034, p=0.039, respectively). It was observed that the Gensini scores of
participants had positive correlations with MDA and AOPP levels (r=0.271, p=0.021; r=0.241, p=0.041,
respectively).
Conclusion: In the present study, it was determined that the severity of coronary artery disease has a
relationship with AOPP and MDA levels. An increase was observed in the levels of these parameters as
the severity of coronary artery disease increased.It is concluded that the AOPP and MDA levels can be
used to determine the degree of coronary artery disease.
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