Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2004, Cilt 2, Sayı 2, Sayfa(lar) 051-057
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The Correlation of Second Trimester Maternal Serum Alpha-Fetoprotein, Human Chorionic Gonadotropin and Unconjugated Estriol with Complications of Pregnancy
Nesibe Polat1, Gürkan Yazıcı2, Gülçin Eskandari1, Burak Çimen1, Handan Çamdeviren3, Uğur Atik1
1Mersin Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Mersin
2Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Mersin
3Mersin Üniversitesi Tıp Fakültesi Biyoistatistik Anabilim Dalı, Mersin
Keywords: Alpha-fetoprotein, Human chorionic gonodoropin, uncongudated estriol, pregnancy complications

Objective: The purpose of this study was to determine the correlation of between second-trimester maternal serum alphafetoprotein, human chorionic gonadotropin b, unconjugated estriol levels and pregnancy complications.

Material and Methods: The data were extracted retrospectively from patient records of 199 women who underwent routine triple testing at 16-20 weeks of pregnancy and delivery notes. The cut-off values were presumed as, 1.5, 2.0, 2.5, 3.0 Multiples of Median , 1.5, 2.0, 2.5, 3 Multiples of Median and 0.6, 0.7, 0.8, 0.9 Multiples of Median for alphafetoprotein, human chorionic gonadotropin-β and unconjugated estriol respectively. The association between these cut off values and pregnancy complications were evaluated.

Results: No association between alphafetoprotein cutoff values and complication incidence was found. If the cut off value of human chorionic gonadotropin-β was presumed to be 1.5, no association was found. On the other hand the cut off values 2.0, 2.5, 3.0 for human chorionic gonadotropin-β were associated with pregnancy associated complications such as preeclampsia, eclampsia fetal growth restriction, preterm labour. When the unconjugated estriol Multiples of Median levels were equal or lower than the 0.6, the complication incidence was found to be higher.

Conclusions: The results of this study indicate that the cut off for human chorionic gonadotropin- and unconjugated estriol may be accepted as 2 and 0,6 Multiples of Median respecively. No association was found between, alphafetoprotein cutoff values and pregnancy complications. But further studies with a greater number of patients will be useful.


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