Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2016, Cilt 14, Sayı 3, Sayfa(lar) 157-165
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Effects of Taurine on Paraoxonase, Arylesterase and Lactonase Activities in Diabetic Rats
Gülben Sayılan Özgün1, Eray Özgün1, Sevgi Eskiocak1, Selma Süer Gökmen1, Necdet Süt2, Mehmet Akıncı1
1Trakya Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Edirne, Türkiye
2Trakya Üniversitesi Tıp Fakültesi, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı, Edirne, Türkiye
Keywords: Streptozotocin-induced diabetes; taurine; paraoxonase; arylesterase; lactonase

Purpose: The aim of the present study was to investigate the effects of taurine on plasma paraoxonase, arylesterase and lactonase activities in streptozotocin-induced experimental diabetes.

Materials and Methods: Thirty-six Sprague-Dawley female rats, which have 204±11 g body weight, were divided into four groups randomly and equally: control, taurine, diabetes and diabetes+taurine. To induce diabetes streptozotocin (40 mg/kg) was injected intraperitoneally to diabetes group and diabetes+taurine group. Taurine (1%) was added to drinking water of taurine group and diabetes+taurine group for 21 days. Plasma paraoxonase, arylesterase and lactonase activities, malondialdehyde and HDL cholesterol levels were measured.

Results: Plasma paraoxonase, arylesterase and lactonase activities and HDL cholesterol levels were significantly decreased whereas plasma malondialdehyde levels were significantly increased in diabetes group when compared with control group. Taurine treatment caused a significant increase on plasma paraoxonase, arylesterase and lactonase activities and a significant decrease on plasma malondialdehyde levels in streptozotocin-induced diabetic rats.

Conclusion: Our study showed that taurine has an increasing effect on plasma paraoxonase, arylesterase and lactonase activities in streptozotocin-induced experimental diabetes. Taurine may be useful for preventing the atherosclerotic complications of diabetes.


[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim