2014, Cilt 12, Sayı 3, Sayfa(lar) 137-146 |
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Biomarkers in Amyotrofic lateral sclerosis disease |
Sevda Ünallı Özmen, Yeşim Özarda |
Uludağ üniversitesi Tıp Fakültesi, Tıbbi Biyokimya, BURSA, Türkiye |
Keywords: Amyotrophic lateral sclerosis; genetic; molecular pathology; biomarker |
Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology
and no effective treatment to date. The cause of the most cases of ALS remains unknown. Research
in ALS has been stimulated by a series of genetic and molecular pathology discoveries. ALS is believed
to be a multifactorial and multi-system) disease. There is an intense need to establish biomarkers sensitive
to diagnosis, prognostic stratification and disease activity of ALS. Based on this review, we mentioned
about some biological markers according to the genetic and molecular pathology reports; in
future studies these all may guide us.
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