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2014, Cilt 12, Sayı 1, Sayfa(lar) 001-007
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Which Method is More Accurate in Patient-side Glucose Monitoring Systems?
Esra Ekiz1, Şermin Acar Duran2, Mihriban Ulaş2
1İstanbul Medeniyet Üniversitesi Göztepe Eğitim Araştırma Hastanesi, İç Hastalıkları, İstanbul, Türkiye
2İstanbul Medeniyet Üniversitesi Göztepe Eğitim Araştırma Hastanesi, Biyokimya, İstanbul, Türkiye
Keywords: Home blood glucose monitoring; hexokinase; glucose 1-dehydrogenase

Objective: Comparison of two patient-side glucometers, Accuchek Active (AC) and Optium Xceed (OP)with autoanalyzer Olympus AU 2700 (OL), which uses the reference method.

Materials and Methods: 44 patients, aged over 18, who attended emergency and internal medicine clinics at Goztepe Training and Research Hospital, were recruited fort he study. 2 cc blood was drawn from the antecubital vein and transefered to Standard tubes with EDTA. All samples were studied in each device twice, mean values were recorded.

Results: Pyrolinquinoline quinon-linked glucose dehydrogenase (GDH) enzyme using bis- (2- hydroxyethyl)- (4-hydroxyiminohexo 2,5-dieniliden)-ammonium chloride as a mediator, was superior to NAD (nicotinamide dinucleotide)-linked GDH enzyme using PQ (phenantroline quinone) as a mediator, in measuring glucose levels closer to the reference method. All measurements with hexokinase method were lower than GDH method and the difference between them showed a linear correlation with increasing glucose levels.

Conclusion: Accuracy of measurements with regards to the reference method should be the point of care in choosing patient-side glucometers. It must be kept in mind that all portable glucometers read higher levels than the reference method and this might be emphasized in education for diabetes.


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