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2011, Cilt 9, Sayı 3, Sayfa(lar) 089-095
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Increased Lp-PLA2 Activity in Obese Adolescents with Insulin Resistance
Ceyda Kabaroğlu1, Ece Onur2, Betül Ersoy3, Bayram Özhan3, Soner Erdin2, Ahmet Var2, Oya Bayındır1
1Ege Üniversitesi Tıp Fakültesi, Klinik Biyokimya Bilim Dalı, İzmir
2Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Manisa
3Celal Bayar Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Pediyatrik Endokrinoloji Bilim Dalı, Manisa
Keywords: Obesity, insulin resistance, 1-Alkyl-2-acetylglycerophosphocholine esterase

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A 2 (Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with insulin resistance.

Materials and Methods: The study involved 65 pubertal obese adolescents with a body mass index (BMI) greater or equal to 95th percentile according to age and gender. In venous blood samples, glucose, insulin, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C), apolipoprotein AI (Apo A), apolipoprotein B100 (Apo B), CRP, IL- 6 and neopterin levels, and Lp-PLA2 activities and in whloe blood glycated hemoglobin (HbA1c) were determined. According to the presence of insulin resistance the study group was divided into two groups. The results were expressed as median (min-max). P <0.05 was accepted for statistical significance.

Results: There was no difference between groups with or without insulin resistance in terms of total cholesterol, triglyceride, HDL-C, LDL-C, Apo A, Apo B, CRP and IL- 6 levels. Neopterin levels were not different between the two groups, but Lp-PLA2 activity was significantly higher in the insulin resistant group than the other group (p=0.003). Significant positive correlations between; HOMA-IR and Lp-PLA2 (rho=0.420, p=0.001), HOMA-IR and BMI (r=0.419, p=0.001) were obtained. Lp-PLA2 correlated inversely both with HDL-C and Apo A (r= - 0.259, p=0.03; r= - 0.362, p=0.001, respectively).

Conclusion: In this study we demonstrated that in obese adolescents with similar lipid profile and systemic inflammatory status, insulin resistance is associated with Lp-PLA2 activity, a marker of vascular inflammation. Our results support the arguments in the favor of early start of atherosclerotic vascular changes in insulin resistant subjects with respect to non-insulin resistant ones.

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