Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2009, Cilt 7, Sayı 1, Sayfa(lar) 023-029
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Leptin, Adiponectin, Oxidized LDL Levels and Paraoxonase Activity in Metabolic Syndrome
Ahmet Solak, Pınar Tuncel
Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir
Keywords: Metabolic syndrome, insulin resistance, leptin, adiponectin, oxidized LDL, paraoxonase

Objective: Metabolic syndrome is a comorbidity of insulin resistance, impaired glucose tolerance, abdominal obesity, hypertension and dyslipidemia and associated with increased risk of cardiovascular disease. The secretion of adipocytokines such as leptin and adiponectin from the increased abdominal adipose tissue plays a key role in the pathophysiology of the syndrome. While LDL oxidation is an important factor in the plaque formation in the vessel wall, HDL particles which contain paraoxonase are important in the protection of LDL from oxidative stress. The aim of the present study was to investigate leptin, adiponectin, oxidized LDL levels and PON1 activity and their correlation in MS.

Materials and Methods: The study group consisted of 52 controls and 67 patients with metabolic syndrome. Total cholesterol, triglyceride, HDL-C, LDL-C, and glucose were measured with colorimetric method. Leptin, adiponectin and oxidized-LDL were measured with commercial kits using enzyme immunoassay method. PON1 activity was measured according to the method of Juretic et al.

Results: In the patient group HOMA index (p=0.000), leptin (p=0.000) levels were higher and adiponectin levels (p=0.001) were lower than the control group. There was no difference in oxidized-LDL concentrations and PON1 activity between the groups, There was a good correlation between leptin levels and waist circumference, HOMA index in both of the groups.

Conclusion: In metabolic syndrome adipocytokines are especially related to abdominal obesity. Although the leptin and adiponectin levels are affected in these patients they are not correlated to oxidized-LDL levels and paraoxonase1 activity.


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