Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2009, Cilt 7, Sayı 1, Sayfa(lar) 001-006
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Relationship Between the Degree of Stuffiness and Levels of C-Reactive Protein in Coronary Artery Disease Without Diabetes
Türkan Yiğitbaşı1, Serkan Kap1, Yasemin Baskın2, Banu Aslan Şentürk1, Nihal Kahya Eren3, Füsun Üstüner1, Oktay Ergene3
1İzmir Atatürk Eğitim ve Araştırma Hastanesi, I. Biyokimya Kliniği, İzmir
2Dokuz Eylül Üniversitesi Tıp Fakültesi, Onkoloji Enstitüsü, İzmir
3İzmir Atatürk Eğitim ve Araştırma Hastanesi, II. Kardiyoloji Kliniği, İzmir
Keywords: Coronary artery disease, diabetes mellitus, CRP, LDL-cholesterol, HDL- cholesterol

Objective: Levels of C-reactive protein might be important, in coronary artery disease regarding long-term risk assessment and prognosis. It has been showed that coronary artery disease is associated with high levels of C-reactive protein whereas the relationship between severity of the disease and levels of C-reactive protein remains controversial. In this study 79 non-diabetic patients, who were admitted between 20.05.2008 - 26.12.2008 to İzmir Atatürk Training and Research Hospital Emergency Service for elective coronary angiography are included. The aim was to examine the relationship between severity of coronary artery disease and levels of C-reactive protein

Material and Methods: Lesions of coronary arteries were graded visually from 0 to 4: Group 0= normal, group 1 = >%70'stenosis in one vessel, group 2 = >%70'stenosis in two vessels, group 3 = %70Õstenosis in three vessels. After a fasting period of 8-10 hours, blood samples were taken and serum levels of C-reactive protein determined by immunoturbidimetric methods. Blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol levels were measured by photometric methods.

Results: Serum C-reactive protein levels; were significantly higher in group 2 compared to group 0, were significantly higher in group 2 and group 3 -compared to group 1 (p<0.001). Only high density cholesterol levels were significantly lower in group 2 compared to group 0 (p<0.024). Negative correlation was found to be existing between serum C-reactive protein levels and use of -blocker (r=-0.244; p<0.05) The number of damaged vessels were correlated negatively with high density cholesterol (r= -0.286; p=0.011) levels and -blocker use (r=-0.237; p<0.05) and positively with age (r=0.358; p<0.01) respectively.

Conclusion: In non diabetic coronary artery disease group, the increase serum levels of C-reactive protein may be beneficial in showing the degree of stuffiness.


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