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2020, Cilt 18, Sayı 3, Sayfa(lar) 129-135
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Oxidative Stress and Trace Element Levels in Adolescent Girls with Vitamin D Deficiency
Gürkan ÇIKIM1, Metin KILINÇ2, Filiz ALKAN BAYLAN2
1Necip Fazıl Şehir Hastanesi, Biyokimya Bölümü, Kahramanmaraş, Türkiye
2Sütçü İmam Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya, Kahramanmaraş, Türkiye
Keywords: Vitamin D, MDA, hemoglobin, zinc, copper

Aim: Physical, sexual, biological, psychological and social changes occur in the adolescent period. Vitamin D is an anti-inflammatory hormone that regulates the body's calcium (Ca) and phosphorus (P) balance, provides bone development, contributes to the formation of the immune system and prevents cancer development. Free radicals; They are molecules that damage structures such as DNA, proteins and lipids. One of the most important indicators of zinc and copper are elements in the structure of metalloenzymes. It is known that zinc has a protective role against oxidative stress and copper forms hydroxyl (OH) ion. In this study, we aimed to investigate whether there is change in MDA levels, which is an indicator of oxidative stress, as well as zinc and copper elements in adolescents with vitamin D deficiency.

Materials and Methods: This study was conducted on 30 adolescents with vitamin D deficiency (Group I) and 30 adolescents with normal vitamin D levels (Group II). Plasma zinc, copper, magnesium, MDA, hemoglobin levels were evaluated in the study.

Results: In copper levels; In the group with vitamin D deficiency (Group I), a statistically significant p <0.05, and a statistically insignificant p> 0.05 increase in MDA levels were found. A statistically significant p <0.05 decrease in zinc levels was found in the vitamin D deficient group (Group I). There was no change in other parameters. According to the analysis, a moderate positive correlation was found between D vit levels and zinc, and a moderate negative correlation between copper.

Conclusion: In this study, we found that along with vitamin D insufficiency, MDA levels and copper, which are indicators of oxidative stress, increased and zinc levels decreased. We think that zinc and copper should be taken into consideration in the regulation of diets of adolescents with vitamin D deficiency for a healthy life.


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