2022, Cilt 20, Sayı 3, Sayfa(lar) 131-135 |
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Interference in the measurement of Hemoglobin A1c: Presence of Hemoglobin D |
Tevfik Noyan, Abdullah Üner, Murat Cihan |
Ordu Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya, Ordu, Türkiye |
Keywords: Glycated Hemoglobins, Hemoglobinopathies, HPLC |
DOI: 10.56615/tkbd.2022.15 |
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HbA1c measurement was performed by the high-performance liquid chromatography (HPLC) method,
and the result was measured as 3.5% (14.75 mmol/mol). Since the HbA1c result was inconsistent with
the other clinical values of the patient, the same sample was run in the variant mode of the instrument
and Hb variant warning was received. The HbD variant was detected in the analysis of the sample and
the HbA1c result was reported as 5.1% (32 mmol/mol). In the presence of a low HbA1c value that is not
suitable for the patient's clinic, the sample should be re-examined considering the presence of Hb
variant. |
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