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2018, Cilt 16, Sayı 3, Sayfa(lar) 141-149
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Plasma Selenium, Zinc, and Copper Levels in Children with Adenoid Hypertrophy
Tugba Arıkan1, Mehmet Kelles2, Selman Sarıca3, Metin Kılınc4
1Kahramanmaras Sutcu Imam University, Education Faculty, Department of Elementary Science Teaching, Kahramanmaras, Turkey
2Malatya Education and Research Hospital, Department of Otolaryngeology, Malatya, Turkey
3Kahramanmaras Sutcu Imam University, Medical Faculty, Department of Otolaryngeology, Kahramanmaras, Turkey
4Kahramanmaras Sutcu Imam University, Medical Faculty, Department of Biochemistry, Kahramanmaras, Turkey
Keywords: Adenoid hypertrophy; selenium; zinc; copper
Abstract
Objective: It has been demonstrated that oxidative stress induced tissue damage plays a role in the pathogenesis of several otolaryngological diseases. The aim of the present study was to evaluate the selenium (Se), zinc (Zn) and copper (Cu) levels in the plasma of children with adenoid hypertrophy (AH).

Material and Methods: The study population consisted of 60 children, 30 healthy children (Group 1) and 30 children with AH (Group 2). Se, Zn, and Cu measurements were taken using an atomic absorption spectrophotometer.

Results: The plasma C-reactive protein (CRP) and Cu levels were significantly higher, and the plasma Se and Zn levels significantly lower, in Group 2 than in Group 1 (p < 0.05). When all the cases were evaluated together, a statistically significant negative correlation was determined between Zn and CRP (r=−0.322, p=0.012) and WBC (r=−0.262, p=0.043), and a positive correlation was found between Se and Zn (r=0.276, p=0.033).

Conclusion: Decreased serum antioxidant trace element Se and Zn and increased Cu in children with AH when compared with healthy controls supported the hypothesis that AH is associated with decreased antioxidant response and increased inflammation.

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