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2007, Cilt 5, Sayı 1, Sayfa(lar) 019-025
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Serum Androgen Levels in Type 2 Diabetic Men and Women
Nihal Yücel, Filiz Eryarsoy, Neslihan Sağlam, Nazan Tunçbilek, Asuman Orçun
Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Bölümü, İstanbul
Keywords: Diabetes mellitus, total testosterone, free testosterone, dehydroepiandrosterone sulphate

Objective: In this study, we investigated the relationship between androgen levels and type 2 diabetes in men and women.

Material and Methods: 99 diabetic patients receiving oral antidiabetic treatment, without any micro and macrovascular complications, without any other chronic disease symptoms, who were not smoking, not consuming alcoho l were included in the study. Age and body mass index matched 37 healthy individuals were included in the control group.

Total testosterone, free testosterone, dehydroepiandrosterone sulphate, glucose and insulin levels were measured in all cases.

Results: In women, glucose (p<0.01) levels were found to be higher in the study group than the control group and no significant differences were found between total testosterone and free testosterone levels.

In men, when the study group was compared with the control group, glucose (p<0.01) levels were found to be higher; total testosterone (p=0.05) and free testosterone (p=0.021) levels were found to be lower.

Dehydroepiandrosterone sulphate values were found lower in both diabetic men and women (p=0.018 and p=0.781 respectively) but this difference was not statistically significant in women. Insulin levels of both diabetic men and women were higher compared with control group but none of them showed statistical significance.

In the study group, when we evaluated the correlation of glucose with the other parameters, in men, a negative correlation between total testosterone (r=-0.413, p=0.002) and free testosterone (r=-0.332, p=0.016) was found; in women no correlation was observed.

Conclusion: Low levels of total testosterone and free testosterone is related with type 2 diabetes in men and insulin may play a regulatory role for dehydroepiandrosterone sulphate levels in both sexes.


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