Aim: Idiopathic hyperandrogenemia is defined as the disease in women with signs of hirsutism and increased serum androgen levels, a normal menstrual cycle, and normal ovarian morphology. In this study, it was aimed to examine the association of Bisphenol A and mono-ethylhexyl phthalate with this disease.

Material and Methods: A total of 91 individuals between the ages of 18–45 were included in the study. The patient group consisted of 43 women with high androgen levels who applied to the endocrine outpatient clinic with signs of hirsutism, and the control group consisted of 48 healthy women with no signs of hirsutism or any additional disease. Bisphenol A and mono-ethylhexyl phthalate were measured in urine by the liquid chromatography-mass spectrometry method.

Results: Urinary Bisphenol A levels were found to be significantly higher in the patient group compared to the control group (1.6 ng/ml; 0.55 ng/ml, p=0.035). Mono-ethylhexyl phthalate levels were found to be significantly higher in the control group compared to the patient group (1.81 ng/ml, 1.66 ng/ml, p=0.01). In logistic regression analysis, odds ratios were 1.91 (95% CI: 1.13–3.24, p<0.05) for BPA, 0.91 (95% CI: 0.81–1.01, p=0.09) for age, 18.74 (95% CI: 3.86–90.85, p<0.05) for fT3, and 1.06 (95% CI: 0.98–1.14, p=0.09) for prolactin.

Conclusion: Investigation of the effect of endocrine-disrupting chemicals in this group, which is less common in the etiology of hyperandrogenemia, made our study unique. The higher Bisphenol A urinary level in the patient group than in the control group suggests the effect of Bisphenol A in patients with idiopathic hyperandrogenemia. The higher level of mono-ethylhexyl phthalate in the control group suggests that more phthalate metabolites should be examined and more studies should be conducted.