Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2021, Cilt 19, Sayı 3, Sayfa(lar) 185-192
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
The Effect of Autoimmunity on NAMPT/Visfatin in Patients with Hypothyroidism
Muzaffer Katar1, Şafak Şahin2
1Tokat Gaziosmanpaşa University Faculty of Medicine, Department of Biochemistry, Tokat, Türkiye
2Tokat Gaziosmanpaşa University Faculty of Medicine, Department of Internal Medicine Tokat, Türkiye
Keywords: Autoimmune, Hashimoto Disease, Hypothyroidism, Nicotinamide Phosphoribosyltransferase, Papillary, Thyroid Cancer, Thyroiditis

Background: NAMPT/visfatin increases inflammation and its serum levels are affected in chronic lowgrade inflammation such as autoimmune disorders, and thyroid cancers.

Aim: We aimed showing how NAMPT/visfatin levels are affected in Hashimoto’s Thyroiditis (HT), a chronic autoimmune thyroiditis (CAT) with hypothyroidism, and thyroid papillary carcinoma (TPCa).

Materials and Methods: This is a cross-sectional case-control study and conducted in 2020. 193 HT patients not yet received treatment and 29 TPCa patients were compared with 150 healthy controls. Visfatin serum concentration was measured by ELISA method,

Results: The highest levels of NAMPT/visfatin were seen in the HT, and the lowest in the control group. HT group had the highest Anti-TPOAb level. TPCa and controls were negative for TPOAb and Anti- Tiroglobulin Ab. Between subclinical and overt hypothyroidism subgroups of HT group; there were significant differences regarding TSH, FreeT3, FreeT4, and Thyroglobulin (p <0.001, p = 0.037, p <0.001, p = 0.001, respectively). In subgroups of TPCa group; there were significant differences regarding TSH and FreeT4 (p <0.001, p = 0.007, respectively). Visfatin concentrations were significantly correlated with FT3 (r = 0.336; p = 0.034).

Conclusions: Visfatin levels in hypothyroidism are regulated by co-existing CAT and are also affected in TPCa and correlates with FT3.


[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim