The importance of laboratory medicine during COVID-19 pandemic has once again become a current issue. With COVID-19 pandemic, very important changes have occurred in terms of laboratory processing. Some of these changes were measures related to employee health, planning regarding the assignment of personnel, changes on the variety and number of tests, innovations in quality standards and the contribution of laboratories to scientific studies. Due to changes in employee health and workload distribution, some precautions were taken and disaster plans were updated. A global effort has spent when all healthcare professionals come up against the biological threat. Interlaboratory collaboration and a multidisciplinary approach have contributed to this effort. This review has been summarized the experienced laboratory processes at local, national and international levels during COVID-19 pandemic.