2021, Cilt 19, Sayı 1, Sayfa(lar) 077-084 |
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The Effect of Smoking on High Sensitivity C-Reactive Protein/Albumin Ratio |
Hüseyin Kurku1, İbrahim Solak2, Yavuz Turgut Gederet3, Mehmet Ali Eryilmaz4 |
1SB Konya Beyhekim Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, Konya, Türkiye 2SB Konya Beyhekim Eğitim ve Araştırma Hastanesi, Aile Hekimliği, Konya, Türkiye 3SB Konya Meram Devlet Hastanesi, Tıbbi Biyokimya, Konya, Türkiye 4SBÜ, Konya Şehir Eğitim ve Araştırma Hastanesi, Genel Cerrahi, Konya, Türkiye |
Keywords: hs-C-reactive protein, hs-CRP/Albumin ratio, smoking, inflammation |
Aim: Smoking is accepted as a risk factor for primary chronic diseases such as cardiovascular diseases
and respiratory system diseases and for cancer development. The aim of this study was to indicate the
increase in inflammation in smokers by using high-sensitivity C-reactive protein (hs-CRP)/Albumin ratio
(AlbR).
Material and Methods: A total of 125 volunteers (M:81;65%, F:44;35%) were included in our study,
including 60 people (M:42,F:18) with an average age of 37.52(±11.82) years in the smoking group and
65 healthy volunteers (M:39, F:26) with an average age of 35.32(±7.66) years in the control group. The
complete blood count parameters, albumin, hs-CRP and hs-CRP/AlbR values of the two groups were
compared.
Results: It was determined that hs-CRP (1.550±3.320) and hs-CRP/AlbR (35.90±75.61) values of the
smoking group were higher than the hs-CRP (0.890±1.210) and hs-CRP/AlbR (20.13±30.38) of the
control group (respectively;p=0.002, p=0.001). However, albumin values (4.37±0.34) were lower than
that of the control group (4.58±0.37)(p<0.001). Leukocyte (WBC), erythrocyte (RBC), lymphocyte counts
and hemoglobin levels of the smoking group were higher than the values of the control group
(respectively; p=0.018, p=0.013, p=0.004). In the correlation analysis of the study group it was found
that hs-CRP and hs-CRP/AlbR had correlations with age, duration of smoking, box/year, body mass index
(BMI), WBC, and neutrophil lymphocyte ratio (NLO).
Conclusion: The smokers had increased levels of hs-CRP and hs-CRP/AlbR, which are an indicator of
inflammation and this increase was found to be associated with the intensity and duration of smoking
exposure. The hs-CRP and hs-CRP/AlbR levels in smokers may be an early indicator for risk of
cardiovascular disease and cancer development in the future.
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