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2021, Cilt 19, Sayı 1, Sayfa(lar) 063-070
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The Serum Ghrelin, Obestatin, and Copeptin Levels During Oral Glucose Tolerance Test In Pregnancy
Büşra Akşit Koldaş, Tevfik Noyan
Ordu University, Medical Faculty, Department of Biochemistry, Ordu, Turkey
Keywords: Ghrelin, obestatin, copeptin, insulin resistance, oral glucose tolerance test

Aim: The aim of this study was (1) to compare the serum insulin, ghrelin, obestatin and, copeptin levels between pregnant and non-pregnant women and (2) investigate the changes in these parameters in pregnant women that measured at before and second hour after 75 gram (g) oral glucose tolerance test (OGTT).

Materials and Method: Thirty pregnant and 27 healthy non-pregnant women were included in the study, and 75 g OGTT was also performed to pregnant women between 24 and 28 weeks of gestation. The venous blood samples of pregnant women were collected 0 and 2 h after a 75 g glucose loading, and also fasting venous blood samples of non-pregnant women were taken for measurement of these parameters. The measurements of ghrelin, obestatin, copeptin, and insulin were performed by ELISA method.

Findings: In pregnant women, glucose and insulin levels measured at 2 h after glucose loading were significantly increased compared to fasting levels of pregnant and non-pregnant women (p=0.000). The serum ghrelin, obestatin, and copeptin levels were not also different between the pregnant and non-pregnant groups (p>0.05). However, 75 g glucose loading did not cause any change on ghrelin, obestatin, and copeptin levels as compared to before and after 2-h of OGTT (p>0.05).

Conclusions: The results of this study concluded that ghrelin, obestatin, and copeptin levels did not differ between those who were pregnant women and those who were not. Another result of this study was that 75 g of glucose loading test in pregnant women could not cause any significant change in these parameters.


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