2020, Cilt 18, Sayı 2, Sayfa(lar) 092-100 |
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Leptin Levels During Oral Glucose Tolerance Test |
Çiğdem Sönmez1, Şenay Arıkan2, Yüksel Koca3, Şemnur Büyükaşık4, Yahya Büyükaşık5, Turan Turhan6 |
1SBÜ Dr. Abdurrahman Yurtarslan Onkoloji Eğitim ve Araştırma H, Klinik Biyokimya Laboratuvarı, Ankara, Türkiye 2Kırıkkale Üniversitesi, İç Hastalıkları Endokrinoloji ve Metabolzma Ana Bilim Dalı, Kırıkkale, Türkiye 3SBÜ Ankara Numune Eğitim ve Araştırma Hastanesi, Klinik Biyokimya Laboratuvarı, Ankara, Türkiye 4SBÜ Bilkent Şehir Hastanesi, İç Hastalıkları Gastroentereloji Kliniği, Ankara, Türkiye sup>5Hacettepe Üniverstiesi, İç Hastalıkları Ana Bilim Dalı, Ankara, Türkiye 6SBÜ Bilkent Şehir Hsatanesi, Klinik Biyokimya Laboratuvarı, Ankara, Türkiye |
Keywords: obesity; leptin; insulin; body mass index; oral glucose tolerance test |
Aim: Leptin is a nonglycolyzed peptide, made of 146amino-acids, that is produced by ob-gene in fat
tissue. Leptin in circulation shows its effects by inhibiting Neuropeptide-Y in central nervous system and
shows its effects on body fat mass by decreasing appetite and increasing energy usage. Because of the
unproportional relation between the leptin levels and weight loss, there must be some other factors
other than body fat mass in its regulation. Starving and feeding have an influence on leptin levels. We
aimed to evaluate the effect of acute glucose administration on circulating leptin levels.
Material and methods: 34 obese and 16 healthy volunteers (Group III) were included in the study and
a75gr oral glucose tolerance test was applied to all cases. The cases were assigned according to the
World Health Organization criteria as; cases who were obese and had impaired glucose tolerance were
grouped as GroupI (n=12) and cases who were obese and had normal glucose tolerance were grouped
as GroupII (n=22). During the oral glucose tolerance test, glucose and insulin analysis were performed
on the blood samples taken from the patients at 0,-30,-60,-90 and,-120 minutes, and leptin analysis
was performed on the blood samples at 0 and 120 minutes. The body mass index of the cases was
calculated.
Results: The BMI of the cases was33.3±7.4kg/m2 in Group I, 38.5±7.4kg/m2 in Group II, and
22.8±2.6kg/m2 in Group III. Leptin levels were59.8±35.7ng/mL in Group I, while it was 69.67±22.5ng /
mL in Group II and 26.6±20.2ng/mL in Group III.
Conclusion: There was a significant (p<0,05) difference in the leptin levels between the study groups
(p<0.05)by ANOVA analysis, while no significant difference was found between the leptin levels of
GroupI and GroupII (p>0.05). There was no signifıcant change in leptin levels in response to acute
glucose administration in all groups(p>0.05).There was positive correlation between leptin levels and
BMI in all groups, while negative correlation was observed with ISI.
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