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2004, Cilt 2, Sayı 3, Sayfa(lar) 091-095
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25 (OH) Vitamin D Levels in Sera of Active Pulmonary Tuberculosis Patients
Füsun Alataş1, Özkan Alataş2, Ömer Çolak2, Sinan Erginel1, Muzaffer Metintaş1, Sema Uslu2
1Osmangazi Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Eskişehir
2Osmangazi Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Eskişehir
Keywords: Tuberculosis, serum 25 (OH) vitamin D, lung, immune response, cellular immunity

Vitamin D and its metabolites, inhibit the growth of mycobacteria in macrophages and shift the immune response from Th1 to Th2. In our study, the role of 25 (OH) vitamin D in the pathogenesis of tuberculosis was investigated by determining its serum levels in active pulmonary tuberculosis. The serum 25 (OH) vitamin D levels were 21.06±16.51 ng/ml (Mean±SD) in active pulmonary tuberculosis patients (n=44), 81.95±67.87 ng/ml in inactive pulmonary tuberculosis patients (n=24) and 67.0±53.25 ng/ml in healthy control subjects (n=20). 25 (OH) vitamin D levels were significantly different in active pulmonary tuberculosis patients when compared with inactive pulmonary tuberculosis and healthy control subjects (p<0.001, for both comparisons). Serum 25 (OH) vitamin D levels increased after treatment in 10 patients in which 25 (OH) vitamin D levels were determined before and after treatment (p<0.05).

In conclusion, the decreased 25 (OH) vitamin D concentrations in patients with active tuberculosis may facilitate the development of active infection.


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