2004, Cilt 2, Sayı 3, Sayfa(lar) 091-095 |
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25 (OH) Vitamin D Levels in Sera of Active Pulmonary Tuberculosis Patients |
Füsun Alataş1, Özkan Alataş2, Ömer Çolak2, Sinan Erginel1, Muzaffer Metintaş1, Sema Uslu2 |
1Osmangazi Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Eskişehir 2Osmangazi Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Eskişehir |
Keywords: Tuberculosis, serum 25 (OH) vitamin D, lung, immune response, cellular immunity |
Vitamin D and its metabolites, inhibit the growth of mycobacteria in macrophages and shift the immune response from Th1 to Th2. In our study, the role of 25 (OH) vitamin D in the pathogenesis of tuberculosis was investigated by determining its serum levels in active pulmonary tuberculosis. The serum 25 (OH) vitamin D levels were 21.06±16.51 ng/ml (Mean±SD) in active pulmonary tuberculosis patients (n=44), 81.95±67.87 ng/ml in inactive pulmonary tuberculosis patients (n=24) and 67.0±53.25 ng/ml in healthy control subjects (n=20). 25 (OH) vitamin D levels were significantly different in active pulmonary tuberculosis patients when compared with inactive pulmonary tuberculosis and healthy control subjects (p<0.001, for both comparisons). Serum 25 (OH) vitamin D levels increased after treatment in 10 patients in which 25 (OH) vitamin D levels were determined before and after treatment (p<0.05).
In conclusion, the decreased 25 (OH) vitamin D concentrations in patients with active tuberculosis may facilitate the development of active infection.
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