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2019, Cilt 17, Sayı 3, Sayfa(lar) 134-139
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Ischemia Modified Albumin Levels in Invasive Ductal Carcinoma and Fibroadenoma Patients
Sibel Bilgili1, Özlem Uğurlu1, Giray Bozkaya1, Nuriye Uzuncan1, Baha Zengel2
1SBÜ İzmir Bozyaka Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, Izmir, Türkiye
2SBÜ İzmir Bozyaka Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, Izmir, Türkiye
Keywords: breast cancer; fibroadenoma; invasive ductal carcinoma; ischemia modified albümin; oxidative stress

Aim: Chronic kidney disease (CKD) is highly prevalent, with increasing numbers of patients affected by the disease world-wide (1). Anemia is a common complica- tion that contributes to the burden of disease associated with CK D, and it impacts negatively on cardiovascular disease, exercise capacity, and quality of life, resulting in significant mortality and morbidity in patients with CKD (2–5). Anemia is currently defined by the World Health Organization (WHO) as a hemoglobin (Hb) level o13 g/dL in men and o12 g/dL in women (6).

Purpose: Impaired oxidative-antioxidative balance plays an important role in the pathogenesis of many diseases like cancer. Ischemia modified albumin (IMA) is altered albumin by free radicals generated from ischemic tissues. The aim of this study was to evaluate the levels of the IMA in newly diagnosed patients with invasive ductal carcinoma and fibroadenoma before the surgery or medical treatment.

Methods: IMA levels were measured in 30 patients which were diagnosed as “invasive ductal carcinoma’’(Group 1), 30 patients as “fibroadenoma’’(Group 2) and in 28 “healthy controls’’(Group 3). An albumin-cobalt binding test was used to define serum IMA in absorbance units (ABSU).

Results: There were statistically significant differences between three groups. IMA levels were significantly higher in the invasive ductal carcinoma group (0.434±0.056 ABSU) compared to fibroadenoma group (0.344±0.135 ABSU) and control group (0.196±0.050 ABSU) (p<0.05), also fibroadenoma group values were significantly higher than the control group (p<0.05).

Conclusion: These findings indicate that serum IMA measurements can be demonstrative of the severity of oxidative stress among patients with breast pathologies. Highest IMA levels in invasive ductal carcinoma group than fibroadenoma and control groups may reflect disease severity in newly diagnosed patients and in the future it may be a new marker in breast cancer.

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