2018, Cilt 16, Sayı 3, Sayfa(lar) 141-149 |
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Plasma Selenium, Zinc, and Copper Levels in Children with Adenoid Hypertrophy |
Tugba Arıkan1, Mehmet Kelles2, Selman Sarıca3, Metin Kılınc4 |
1Kahramanmaras Sutcu Imam University, Education Faculty, Department of Elementary Science Teaching, Kahramanmaras, Turkey 2Malatya Education and Research Hospital, Department of Otolaryngeology, Malatya, Turkey 3Kahramanmaras Sutcu Imam University, Medical Faculty, Department of Otolaryngeology, Kahramanmaras, Turkey 4Kahramanmaras Sutcu Imam University, Medical Faculty, Department of Biochemistry, Kahramanmaras, Turkey |
Keywords: Adenoid hypertrophy; selenium; zinc; copper |
Objective: It has been demonstrated that oxidative stress induced tissue damage plays a role in the
pathogenesis of several otolaryngological diseases. The aim of the present study was to evaluate the
selenium (Se), zinc (Zn) and copper (Cu) levels in the plasma of children with adenoid hypertrophy (AH).
Material and Methods: The study population consisted of 60 children, 30 healthy children (Group 1)
and 30 children with AH (Group 2). Se, Zn, and Cu measurements were taken using an atomic
absorption spectrophotometer.
Results: The plasma C-reactive protein (CRP) and Cu levels were significantly higher, and the plasma
Se and Zn levels significantly lower, in Group 2 than in Group 1 (p < 0.05). When all the cases were
evaluated together, a statistically significant negative correlation was determined between Zn and CRP
(r=−0.322, p=0.012) and WBC (r=−0.262, p=0.043), and a positive correlation was found between Se
and Zn (r=0.276, p=0.033).
Conclusion: Decreased serum antioxidant trace element Se and Zn and increased Cu in children with
AH when compared with healthy controls supported the hypothesis that AH is associated with decreased
antioxidant response and increased inflammation.
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