2015, Cilt 13, Sayı 3, Sayfa(lar) 089-094 |
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The Evaluation of Measurement Uncertainty for TSH, FT4 and FT3 Tests |
Yasemin Oğul1, Mahmut Şenyurt1, Konca Altınkaynak1, Hülya Aksoy2, Fatih Akçay2 |
1Erzurum Bölge Eğitim ve Araştırma Hastanesi, Tıbbi biyokimya, Erzurum, Türkiye 2Atatürk Üniversitesi Tıp Fakültesi Tıbbi Biyokimya Anabilim Dalı, Tıbbi biyokimya, Erzurum, Türkiye |
Keywords: Thyroid stimulating hormone, free thyroxine, free triiodothyronine, uncertainty |
Purpose: A parameter associated with the result of a measurement that characterises the dispersion of
the values that could reasonably be attributed to the measurand is defined as measurement uncertainty
(U). Measurement uncertainty is very important for the clinician to provide medical judgement,
diagnosis and treatment. The aim of this study was to determine the measurement uncertainty of fT4,
fT3 and TSH parameters in our laboratory.
Material and Methods: In this study, measurement uncertainty calculation was done using Nordtest
guide model. Standard, combined and expanded uncertainty values were calculated with this model.
Results: Expanded uncertainty was calculated 17.93% for TSH. We found measurement uncertainty of
fT4 and fT3 were % 8.83 and %9.13, respectively. Expanded uncertainty of fT4 was found to be higher
when compared to %TEa values of Westgard.
Conclusion: All changes may affect the uncertainty in the laboratory. Therefore, it must be constantly
monitored and uncertainty estimates should be improved by adding more data.
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