2015, Cilt 13, Sayı 2, Sayfa(lar) 079-082 |
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Effect of Anticoagulants on Complete Blood Count: EDTA-Dependent Thrombocytopenia |
Didem Barlak Keti1, Sabahattin Muhtaroğlu1, Nihat Kalay2 |
1Erciyes Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye 2Erciyes Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kayseri, Türkiye |
Keywords: Thrombocytopenia; edetic acid; citric acid |
This case is presented to emphasize the EDTA-dependent PTP (pseudothrombocytopenia) that should
be considered as a possible cause of low platelet count and evaluate the effect of different
anticoagulants on complete blood count (CBC). The CBC and blood smears, of the patient who was
been thought to have pseudothrombocytopenia, were performed in blood samples with EDTA, sodium
citrate and lithium heparin. The platelet counts obtained from blood samples containing EDTA
decreased over time. However, platelet counts in blood samples containing citrate and heparin were
within the reference range. Platelet clumps were found in the blood smears from blood samples
containing EDTA. There was no apparent change except platelet, leukocyte counts and platelet indices.
EDTA-dependent PTP should be considered in the presence of pseudothrombocytopenia. In such cases,
dilution factor should be considered for leukocyte, erythrocyte, platelet counts, platecrit, hemoglobin ve
hematocrit values repeated in blood samples with citrate.
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