2014, Cilt 12, Sayı 3, Sayfa(lar) 131-136 |
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Determination of Vitamin B12 and Folic Acid Reference Intervals at Kartal District |
Yalçın Önder1, Sehavet Tezcan2, Özlem Hürmeydan Kadılar3, Lale Köroğlu Dağdelen4, Özlem Çakır Madenci4, Nihal Yücel4, Asuman Orçun4 |
1Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Halk Sağlığı, TOKAT, Türkiye 2M.Enver Şenerdem Torbalı Devlet Hastanesi, Tıbbi Biyokimya, İZMİR, Türkiye 3Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, SAKARYA, Türkiye 4Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İSTANBUL, Türkiye |
Keywords: Vitamin B12; Folic acid; Reference interval |
Purpose: The purpose of this study is to determine serum B12 and folic acid reference values that can
be used in our hospital district population.
Materials and Methods: 300 healthy individuals were chosen according to CLSI Approved Guideline
C28-A. Serum levels of vitamin B12 and folic acid were analyzed by ADVIA Centaur XP immunoassay
System. The reference intervals are calculated using Analyse-it for Microsoft Excel Version 2.20 program.
Results: The mean±SD of vitamin B12 level was 301,57±114,6 pg/ml (297,19±111,6 pg/ml male,
304,97±117,2 pg/ml in female), the mean±SD of folate level was 8,70±3,90 ng/ml (8,54±4,04 ng/ml in
male, 8,81±3,81 ng/ml in female). Vitamin B12 reference intervals were found as 155-639 pg/ml. Folate
reference intervals were found as 2,87-19,49 ng/ml.
Conclusion: The reference values that we found in our study were different from the values recommended
by the manufacturer company. We think that these values reflect our hospital population more
truly than manufacturer's and should be used as reference intervals.
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