2014, Cilt 12, Sayı 1, Sayfa(lar) 057-063 |
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New biomarkers in faciliating diagnosis of ovarian cancer: OVA1 and ROMA |
Nilgün Tekkeşin |
Şişli Memorial Hastanesi, Biyokimya, İstanbul, Türkiye |
Keywords: ovarian cancer; CA-125 antigen |
Ovarian cancer has often been described as a “silent killer,” but recent studies have shown that there
are symptoms that appear in the early stages of the disease. Recognition of these symptoms is critical
because early diagnosis improves the probability of cure. Use of serum biomarkers for the diagnosis of
epithelial ovarian cancer is an active area of investigation. Biomarkers or panels of biomarkers are
generally used in combination with each other or with other findings (eg, ultrasound). Only a few
biomarkers are commercially available. Cancer antigen 125 (CA-125) has been the focus of most
investigations and is used most extensively. Other diagnostic tests for epithelial ovarian cancer include
human epididymis protein (HE4), the OVA1 panel (overian canser test1), and the Risk of Malignancy
Algorithm (ROMA).
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