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2013, Cilt 11, Sayı 2, Sayfa(lar) 059-066
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Pregnancy Associated Plasma Protein A and C-reactive Protein in Pre-Eclamptic Pregnants
Gökhan Utku1, Sembol Türkmen Yıldırmak1, Müberra Vardar1, Ekrem Özakın2, Yüksel Gülen Özbanazı1, Veli Mihmanlı2, Hatice Birgül Ayabakan1, Hülya Çerçi1
1SB Okmeydanı Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İstanbul
2SB Okmeydanı Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul
Keywords: Pre-eclampsia; pregnancy associated plasma protein-A; C-reactive protein

Objective: Pre-eclampsia is a pregnancy specific form of hypertension and a multisystem disorder of maternal and placental origin. Pregnancy associated plasma protein-A (PAPP-A) is a insulin like growth factor binding protein 4- degrading metalloproteinase. The aim of this study was to measure and compare serum PAPP-A levels and to investigate a possible correlation between C-reactive protein (CRP), an indicator of tissue damage and inflammation, in third trimester pre-eclamptic and healthy pregnant women

Materials and Methods: The study consisted of 27 pregnant women with pre-eclampsia symptoms and 26 healthy pregnant women similar in terms of gestational age, maternal age and parity. Both groups were in the third trimester. Serum PAPP-A and CRP levels were measured by chemiluminescence and nephelometric methods, respectively.

Results: Maternal serum PAPP-A and CRP levels were higher in pre-eclamptic women than healthy pregnant group (mean ± SD, 99.63±64.20; 64.00±39.90 mIU/mL, p<0.05; 34.66±25.70; 10.18±7.37 mg/L, p<0.001, respectively). No correlation was found between serum PAPP-A and CRP levels in the study groups.

Conclusion: High CRP levels in pre-eclamptics is an indicator for increased inflammation. Elevated PAPP-A levels were thought to be the result of induced expression of PAPP-A gene which is associated with increased cytokines as a result of vascular damage caused by a trophoblastic invasion defect. Statistically higher significance in CRP elevation than PAPP-A in pre-eclamptics compared to healthy pregnants, demonstrates that CRP levels may be a better diagnostic indicator.


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