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2012, Cilt 10, Sayı 1, Sayfa(lar) 009-020
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Tissue and Serum VEGF-A, Endostatin and S100A4 Levels in Women with Breast Tumour
Yılmaz Özalp1, Merih Güray Durak2, Sezer Uysal3, Ali Sevinç4, Serdar Saydam4, Tülay Canda2, Banu Önvural3
1Elbistan Devlet Hastanesi, Tıbbi Biyokimya, Kahramanmaraş
2Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İzmir
3Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir
4Dokuz Eylül Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İzmir
Keywords: Breast cancer, VEGF-A, endostatin

Objective: Growth, invasion and metastase potential of solid tumours like breast cancer depends on the presence of angiogenesis. The purpose of this study is to investigate the tissue expression of VEGF-A, ES, and S100A4 and to determine their serum values in patients with benign breast disease, breast cancer with axillary metastasis and breast cancer without axillary metastasis. Correlation of tissue and serum parameters with clinicohistopathological variables and angiogenic balance in predicting metastasis were also investigated.

Materials and Methods: The study was conducted on 32 patients with benign breast diseases, 39 patients with breast cancer without axillary node metastases and 18 patients with breast cancer having axillary node metastases. Tissue expression of VEGF-A, ES, S100A4 proteins were determined by immunohistochemistry and serum levels by ELISA.

Results: No significant difference was found for tissue expression of VEGF-A, ES, and S100A4 between the patient groups. Serum VEGF-A and VEGF-A/ES ratio were significantly increased in the metastasis group when compared with the benign group (p=0.006; and p=0.010). Also serum VEGF-A/ES ratio was significantly higher in the metastasis group than the non-metastasis malign group (p=0.048). Serum VEGF-A and VEGF-A/ES ratio were significantly increased in advanced stage patients (p=0.033; p=0.014). A significant positive correlation existed between the number of involved lymph nodes and serum VEGF-A levels (r=0.596; p=0.012). Serum VEGF-A levels were significantly increased in those who had lymphovascular invasion (p=0.034).

Conclusion: We think that S100A4 could not be used as a marker showing disease state (differentiating metastasis from non-metastasis) in breast tumours. However serum VEGF-A/ES ratio could be used for this purpose and increased serum VEGF-A levels could be an indicator for proceeding to metastatic process.


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