2011, Cilt 9, Sayı 3, Sayfa(lar) 083-088 |
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May Cystatin C be Used in the Early Detection of Diabetic Nephropathy? |
Gülfer Öztürk1, Zeynep Giniş1, Hülya Akdeniz1, Tuncay Delibaşı2, Namık Delibaş1 |
1S.B. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Biyokimya Bölümü, Ankara 2S.B. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Endokrinoloji Bölümü, Ankara |
Keywords: Type 2 Diabetes Mellitus, cystatin C, diabetic nephropathies |
Objective: Cysta tin C has been proposed for the estimation of glomerular filtration rate (GFR). This
study was designed to evaluate cystatin C levels in Type 2 Diabetes Mellitus (DM) as an early marker
of diabetic nephropathy.
Materials and Methods: A total of 117 patients with type 2 DM, 87 patients with normoalbuminuria
and 30 patients with microalbuminuria, were enrolled in this study. Serum glucose, creatinine,
cystatin C, whole blood HbA1c and urine microalbumin levels were determined in all groups. GFR is
estimated using the Modification of diet in renal disease (MDRD) equation.
Results: Cystatin C, creatinine, estimated GFR(eGFR) levels are significantly higher than in patients
with microalbuminuria compared to patients with normoalbuminuria. Patients with eGFR < 60
mL/min/1.73 m2 had higher cystatin C and creatinine levels with respect to the group with eGFR ≥ 60 mL/min/1.73 m2. When the patients were subgrouped acording to their ages cystatin C levels
increased with age.
Conclusions: Cystatin C may be used for early detection of diabetic nephropathy in type 2 DM ,
however it is not superior to creatinine.
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