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2011, Cilt 9, Sayı 2, Sayfa(lar) 067-075
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Intestinal Cholesterol Transport Proteins
Emine Bozkurt1, Ceyda Kabaroğlu2
1Ege Üniversitesi Tıp Fakültesi Hastanesi, Tıbbi Biyokimya Anabilim Dalı, İzmir
2Ege Üniversitesi Tıp Fakültesi Hastanesi, Tıbbi Biyokimya Anabilim Dalı, Klinik Biyokimya Bilim Dalı, İzmir
Keywords: Cholesterol, Niemann Pick Disease, ezetimibe

The direct link between cardiovascular disease and plasma cholesterol levels has been clearly described. Therapeutic interventions for lowering plasma cholesterol levels have a great significance in prevention of cardiovascular diseases. In enterocytes, numerous transport molecules in charge of cholesterol absorption are defined. These are; fatty acid translocase /cluster determinant 36 (FAT/CD36), scavenger receptor class B type 1 (SR-B1), Nieman Pick C1-Like 1 (NPC1L1), ATP Binding Cassette transporter family (ABCA1,ABCB1,ABCG5/ABCG8), caveolin-1(CAV1) and annexin-2 (ANXA2). Studies highlighting functional aspects and metabolic regulations of intestinal cholesterol transport proteins may reveal new strategies in preventing and/or therapeutic interventions for cardiovascular and cerebrovascular diseases. In this review, recent experimental and clinical information on intestinal cholesterol transport proteins have been summarized.

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