Objective: Stroke, in all over the world, the one of the leading causes of morbidity and mortality especially in the geriatric population. Oxidative stress has an important role in pathophysiology of ischemic stroke. Malondialdehyde (MDA) is an important parameter of oxidative stress is a good indicator of lipid peroxidation. Paraoxanase (PON1) is synthesized in the liver and secreted in the blood, where it associates with high-density lipoprotein. PON1 might play an important physiological role in lipid metabolism through protecting against the development of atherosclerosis. The purpose of this study, by evaluating the concentration of MDA as indices of oxidative stress, to investigate the relationship between PON1 with oxidative stress in ischemic stroke.

Materials and Methods: Total of 72 patients with acute ischemic stroke, admitted and treated in Neurology Clinic in Rize Education and Training Hospital and 72 control, had no stroke or any systemic disorder have been included. Malonyldialdehyde (MDA) and paraoxonase (PON) enzyme activities have been determined using spectrophotometric method, in both patient and controls.

Results: Compared with the control group, serum MDA levels were higher in patients with ischemic stroke and lower antioxidant activity of PON1 (p<0.05).

Conclusion: These findings show that oxidant and antioxidant mechanisms are important in pathophysiology of ischemic strokeÕs process.