Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2011, Cilt 9, Sayı 1, Sayfa(lar) 031-038
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Fatty Acid Binding Proteins
Birsen Tuğlu, Sezer Uysal
Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir
Keywords: Fatty acid-binding proteins, FABP, A-FABP

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain fatty acids and eicosanoids with high affinity. They play a role in lipid transport to the specific compartments in the cell. Since the initial discovery of FABPs in 1972, at least nine members have been identified. Adipocyte FABP (A-FABP) is highly expressed in the adipose tissue and macrophages. A-FABP deficient mice exhibited reduced hyperinsulinaemia and insulin resistance in the context of both dietary and genetic obesity. Recent studies have shown that, inhibition of A-FABP has potential therapeutic effects against insulin resistance, diabetes, fatty liver and atherosclerosis. In this review, we focused on the structure and functions of FABPs, and the role of A-FABP on the metabolic processes and possible therapeutic approaches.

[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim