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2010, Cilt 8, Sayı 2, Sayfa(lar) 075-089
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Asymmetric Dimethylarginine and it's Clinical Significance
Özben Özden Işıklar1, Işıl Mutaf2
1Nenehatun Kadın Doğum Hastanesi, Tıbbi Biyokimya, Erzurum
2Ege Üniversitesi Tıp Fakültesi, Klinik Biyokimya, İzmir
Keywords: Asymmetric dimethylarginine, nitric oksid, endotel disfunction, cardiovascular risk factors

Asymmetric dimethylarginine (ADMA) is an amino acid that looks like arginine and exists in plasma, urine and tissues. ADMA occurs naturally by methylation of arginine remnants in proteins and the studies about it increases every day. ADMA, as a major inhibitor of nitric oxide sentase is accepted as cardiovascular risk factor. In this review, the knowledge about metabolism, the relation of ADMA with several patologies, primarily endothelial dysfunction and the measurement methods were overviewed and the results of clinical and experimental studies were discussed.

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