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2009, Cilt 7, Sayı 3, Sayfa(lar) 093-099
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The Relationship Between Severity of Coronary Artery Disease and Serum GGT Levels
Banu Arslan Şentürk1 Serkan Kap1, Nihal Kahya2, Oktay Ergene2, Füsun Üstüner1
1Atatürk Eğitim ve Araştırma Hastanesi, I. Biyokimya ve Klinik Biyokimya Bölümü, İzmir
2Atatürk Eğitim ve Araştırma Hastanesi, II. Kardiyoloji Kliniği, İzmir
Keywords: Coronary artery disease, Gamma glutamyl transferase, LDL cholesterol, HDL cholesterol

Objective: It has been known that levels of GGT might be important, in coronary artery disease for long-term risk assessment and determining prognosis. Relationship between coronary artery disease and levels of GGT was found whereas relationship severity of coronary artery disease and levels of C-reactive protein is controversial. The purpose of this study is to investigate the relationship between severity of coronary artery disease and levels of GGT.

Material and Methods: In this study included 132 patients, admitted during 20.05.2008 - 26.12.2008 to Üzmir Atatürk Training and Research Hospital II. Cardiology departmant for elective coronary angiography. Lesions in coronary arteries were graded visually from 0 to 4: Grup 0 = normal, grup 1 = >70%'stenosis in one vessel, grup 2 = >70%'stenosis in two vessels, grup 3 = 70%'stenosis in three vessels. In the blood taken after fasting 8-10 hours, the serum levels of GGT, blood glucose, uric acid, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol levels determined by photometric methods.

Results: Compared to control group, serum GGT levels were markedly higher in patients-group (p=0.00). When patients were classified to 3 groups according to number of the occluded vessels, serum GGT levels significantly higher in group 1 and 2 compared to control group (p<0.05). There was not a statististically significant difference in group 3 and control group in terms of GGT levels (p>0.05). GGT levels did not differ among 3 groups (p>0.05). There were no statistically significant difference between GGT levels of patients who had hypertension or diabetes mellitus and hadn't. GGT levels did not differ between smokers and non-smokers. Serum GGT was not found as an independent risk factor for coranary artery disease when logistic regression analysis was performed.

Conclusion: Our results showed a significant association between coronary artery disease and GGT but not showed a relationship between severity of disease and serum GGT levels.


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