Objective: It has been known that levels of GGT might be important, in coronary artery disease for long-term risk assessment and determining prognosis. Relationship between coronary artery disease and levels of GGT was found whereas relationship severity of coronary artery disease and levels of C-reactive protein is controversial. The purpose of this study is to investigate the relationship between severity of coronary artery disease and levels of GGT.

Material and Methods: In this study included 132 patients, admitted during 20.05.2008 - 26.12.2008 to Üzmir Atatürk Training and Research Hospital II. Cardiology departmant for elective coronary angiography. Lesions in coronary arteries were graded visually from 0 to 4: Grup 0 = normal, grup 1 = >70%'stenosis in one vessel, grup 2 = >70%'stenosis in two vessels, grup 3 = 70%'stenosis in three vessels. In the blood taken after fasting 8-10 hours, the serum levels of GGT, blood glucose, uric acid, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol levels determined by photometric methods.

Results: Compared to control group, serum GGT levels were markedly higher in patients-group (p=0.00). When patients were classified to 3 groups according to number of the occluded vessels, serum GGT levels significantly higher in group 1 and 2 compared to control group (p<0.05). There was not a statististically significant difference in group 3 and control group in terms of GGT levels (p>0.05). GGT levels did not differ among 3 groups (p>0.05). There were no statistically significant difference between GGT levels of patients who had hypertension or diabetes mellitus and hadn't. GGT levels did not differ between smokers and non-smokers. Serum GGT was not found as an independent risk factor for coranary artery disease when logistic regression analysis was performed.

Conclusion: Our results showed a significant association between coronary artery disease and GGT but not showed a relationship between severity of disease and serum GGT levels.