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2003, Cilt 1, Sayı 2, Sayfa(lar) 061-067
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Lipid Peroxidation and Serum Iron Parameters in People with Alcohol Addiction
Ferah Armutcu1, Ahmet Gürel1, Sinan Kurtman1, A. Görkem Mungan1, Murat Ünalacak2
1Karaelmas Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Zonguldak
2Karaelmas Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim Dalı, Zonguldak
Keywords: Alcohol, serum iron, ferritin, lipid peroxidation, GGT

Alcohol addiction is one of the leading reasons of liver diseases in many countries. Hepatic steatosis, alcoholic hepatitis, hepatic fibrosis and cirrhosis can be mentioned among the diseases resulting due to alcohol addiction. In recent years, studies have been focused on effect oxidant stress and iron, a free radical agent which is one of the transition metals, in the process of pathological changes and mentioned diseases caused by alcohol.

In this study, 25 alcohol addict males were taken as the study group and 26 healthy, non-alcoholic males were taken as control, and it was aimed to measure and compare serum levels of Malondialdehyde, which is an indicator of lipid peroxidation, serum iron parameters and ALT, AST and GGT levels. While malondialdehyde level was studied with TBA reaction in spectrophotometer, the other parameters were studied by autoanalyser using specific kits.

While MDA (p<0.01), serum iron (p<0.01), ferritin (p<0.01), transferin saturation (p<0.01) and GGT (p:0.001) were found to be higher in the study group than the control, there was no statistically significant difference of ALT and AST levels between the groups. There was a positive and significant correlation between serum MDA levels and serum iron (r=0.531, p<0.001), ferritin (r=0.504, p<0,001) and GGT (r=0.496, p<0.001) levels.

According to these results, it was concluded that the alterations observed due to alcohol abuse might be as a result of free radical damage and serum iron and ferritin levels might contribute to lipid peroxidation and prooxidant effect of alcohol in this process.


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